PROPOLEOS E HIPERTENSION
1: Cardiovasc Toxicol. 2005 Fall;5(4):391-6.
Role of vagal activity on bradicardic and hypotensive effects of caffeic acid phenethyl ester (
Iraz M, Fadillioglu E, Tasdemir S, Erdogan S.
Department of Pharmacology, Medical Faculty of
Caffeic acid phenethyl ester (
PMID: 16382176 [PubMed - in process]
2: Biol Pharm Bull. 2005 Oct;28(10):1909-14.
Antihypertensive effects of Brazilian propolis: identification of caffeoylquinic acids as constituents involved in the hypotension in spontaneously hypertensive rats.
Mishima S, Yoshida C, Akino S, Sakamoto T.
Nagaragawa Research Center, API Co., Ltd; 692-3 Yamasaki, Nagara,
Brazilian propolis was extracted with water or various concentrations of ethanol and were administered orally to spontaneously hypertensive rats (SHR) and the effects on blood pressure and heart rate were determined. Single oral administration of 100 mg/kg of propolis extracts decreased the blood pressure in SHR. Significant decrease in blood pressure was observed with propolis extracted with 25 and 70% ethanol. SHR were given orally 5 mg/kg of propolis extracted with 25 or 70% ethanol, twice a day for 28 d and the effects on blood pressure and heart rate were compared with control rats. While the blood pressure in the control group increased day by day, the increase was slower in rats treated with 25 and 70% ethanol extracts of propolis. The hypotensive activity of propolis extracted with 25% ethanol was more significant compared with control group than with 70% ethanol. Di- and tri-caffeoylquinic acids (CQAs) were found to be characteristic components of propolis extracted with 25% ethanol. A single oral administration of 3,4-diCQA, 3,5-diCQA, and 3,4,5-triCQA each at a dose of 10 mg/kg were conducted in SHR. These three components were found to have antihypertensive effects and therefore contribute to the antihypertensive effects of propolis extract. These results suggest that 25% ethanol extract of propolis is useful for prevention and treatment of hypertension.
PMID: 16204944 [PubMed - indexed for MEDLINE]
3: Clin Exp Pharmacol Physiol. 2004 Dec;31 Suppl 2:S29-30.
Anti-hypertensive effects of brazilian propolis in spontaneously hypertensive rats.
Kubota Y, Umegaki K, Kobayashi K, Tanaka N, Kagota S, Nakamura K, Kunitomo M, Shinozuka K.
Department of Pharmacology,
SUMMARY 1. Changes in the cardiovascular parameters of Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were examined following a 4-week diet of either Brazilian propolis or Eucommia uloides OLIVER (tochu).
PMID: 15649281 [PubMed - in process]
4: Fitoterapia. 2002 Nov;73 Suppl 1:S1-6.
Propolis, an old remedy used in modern medicine.
Castaldo S, Capasso F.
Department of I.N.P.S. of
Propolis is one of the few natural remedies that has maintained its popularity over a long period of time. The pharmacologically active molecules in the propolis are flavonoids and phenolic acids and their esters. These components have multiple effects on bacteria, fungi and viruses. In addition, propolis and its components have anti-inflammatory and immunomodulatory activities. Moreover, propolis has been shown to lower blood pressure and cholesterol levels. However, clinical studies to substantiate these claims are required.
PMID: 12495704 [PubMed - indexed for MEDLINE]
5: Arzneimittelforschung. 1978;28(2):291-2.
Biological properties and clinical application of propolis. X. Preliminary pharmacological evaluation of ethanol extract of propolis (EEP).
Kleinrok Z, Borzecki Z, Scheller S, Matuga W.
A study consisting of an examination of the acute toxicity of ethanol extract of propolis (EEP) in mice, its effect on spontaneous movement in mice and rats, its analgesic properties and its influence on body temperature in mice was conducted. Also examined was the activity of EEP on animals under the influence of narcotics and spontaneous movement under the influence of amphetamine, its effects on blood pressure and respiration in rats. The results of these examinations indicate that EEP injected i.p. has a weak general effect on the experimental animals.
PMID: 580395 [PubMed - indexed for MEDLINE]